Antibody Drug Conjugates Market Landscape: Emerging Regions and Their Potential

 The global antibody drug conjugates market size was estimated at USD 11.29 billion in 2023 and is projected to grow at a CAGR of 9.2% from 2024 to 2030. This can be attributed to the presence of a robust R&D pipeline. This, coupled with the growing incidence of cancer and increased demand for low-toxicity & effective drugs, is expected to drive market growth. Some of the key Antibody Drug Conjugates (ADCs) currently available in the market are Kadcyla (Genentech/Roche), Adcetris (Seattle Genetics), Enhertu (AstraZeneca/Daiichi Sankyo), Besponsa (Pfizer), Mylotarg (Pfizer), and Polivy (Genentech/Roche). ADCs are a novel category of drugs composed of an antibody linked-via a chemical linker-to a cytotoxic drug.

 

Conventional chemotherapy is intended to eradicate fast-growing tumor cells. However, it can also damage healthy proliferating cells, which may produce undesirable effects. In contrast, ADC is designed to upsurge the efficacy of treatment and decrease systemic toxicity. In this market, the landscape is influenced by reimbursement policies, a crucial factor in developed economies. The production and research costs of ADC drugs are high compared to conventional treatments, such as monoclonal antibodies and chemotherapy. This results in a higher overall treatment cost, which poses a challenge for reimbursement coverage. For instance, a negative review was given by the National Centre for Pharmacoeconomics in Ireland in February 2020 for Roche's Kadcyla (trastuzumab emtansine).

 

Gather more insights about the market drivers, restrains and growth of the Global Antibody Drug Conjugates Market

 

Detailed Segmentation:

Application Insights

The breast cancer segment dominated the market in 2023 with a revenue share of 47.76% owing to factors, such as a rise in incidence, promising pipeline products, and high adoption of Kadcyla. Trodelvy, Enhertu, and Kadcyla are the products approved for the treatment of breast cancer. The label expansion of Kadcyla to include patients with early breast cancer and the recent approval of Enhertu & Trodelvy are likely to drive segment growth. The blood cancer segment is expected to grow at a high CAGR from 2024 to 2030.

 

Product Insights

The Kadcyla segment held the largest revenue in the ADC space in 2023. The surge in breast cancer cases, coupled with heightened approvals for ADCs tailored for breast cancer treatment, propels the market's upward trajectory. F. Hoffmann-La Roche Ltd. announced approval for Kadcyla in China's rapidly expanding industry in January 2022 marking a pivotal development.

 

Target Insights

The HER2 or human epidermal growth factor receptor 2 target type segment held the largest market share in 2023. HER2 is a pivotal target. It plays a crucial role in breast cancer treatment, where overexpression is common. ADCs designed to target HER2 work by delivering potent drugs directly to cancer cells, minimizing damage to healthy cells, and enhancing therapeutic efficacy. Owing to all such factors, its adoption is high, which contributed to the segment’s industry dominance.

 

Technology Insights

The cleavable linker segment accounted for the largest revenue share of 72.43% in 2023. The ability of cleavable linkers to remain stable in the bloodstream for longer duration & release of cytotoxins from ADCs makes them the most popular used technology for an effective outcome of ADCs in cancer treatment. For instance, in 2020, Seagen’s & Takeda’s Adcetris was approved by NMPA for use in the treatment of relapsed Hodgkin's lymphoma and relapsed systemic anaplastic large cell lymphoma sALCL in China. Such factors are expected to drive the cleavable linker segment growth.

 

Browse through Grand View Research's Healthcare Industry Research Reports.

 

  • Aesthetic Lasers Market: The global aesthetic lasers market size was estimated at USD 1.60 billion in 2024 and is projected to grow at a CAGR of 16.9% from 2025 to 2030.

 

  • Vascular Closure Devices Market: The global vascular closure devices market size was valued at USD 1.56 billion in 2024 and is projected to grow at a CAGR of 5.7% from 2025 to 2030.

 

 

Regional Insights

The North America antibody drug conjugate market accounted for the largest revenue share of 52.54% in 2023. Increased awareness about ADCs among healthcare professionals and favorable reimbursement policies are driving market growth. North America is expected to witness significant growth over the forecast period owing to increased awareness about current treatment therapies, favorable reimbursement policies, significant R&D expenditure, and improved patient affordability. Some of the key players operating in this region are Seagen, Inc.; F. Hoffmann La-Roche Ltd.; Gilead Sciences Inc.; and Pfizer Inc.

 

Key Antibody Drug Conjugates Company Insights

Some of the key players operating in the market include Seagen, Inc., (previously Seattle Genetics, Inc.); Takeda Pharmaceutical Company Limited; AstraZeneca PLC, F. Hoffmann-La Roche Ltd.; Pfizer, Inc.; ImmunoGen, Inc.; Gilead Sciences, Inc. (acquired Immunomedics); and Daiichi Sankyo Company Ltd. Companies like F. Hoffmann-La Roche Ltd. hold key products, such as Kadcyla (ado-trastuzumab emtansine) and Polivy (polatuzumab vedotinpiiq). Kadcyla is a HER2-targeted antibody indicated for the treatment of Metastatic Breast Cancer (MBC) and Early Breast Cancer (EBC). Polivy is used in combination with bendamustine and rituximab for the treatment of adults with diffuse large B-cell lymphoma who have received at least 2 prior therapies.

 

Mersana Therapeutics, Inc., Heidelberg Pharma, and ADC Biotechnology are some of the emerging participants in the antibody drug conjugates market.

 

Key Antibody Drug Conjugates Companies:

The following are the leading companies in the antibody drug Conjugates market. These companies collectively hold the largest market share and dictate industry trends.

 

  • Seagen, Inc.
  • Takeda Pharmaceutical Company Ltd.
  • AstraZeneca
  • Hoffmann-La Roche Ltd.
  • Pfizer, Inc.
  • Gilead Sciences, Inc.
  • Daiichi Sankyo Company Ltd.
  • GlaxoSmithKline Plc
  • Astellas Pharma, Inc.
  • ADC Therapeutics SA

 

Order a free sample PDF of the Antibody Drug Conjugates Market Intelligence Study, published by Grand View Research.

Comments

Post a Comment

Popular posts from this blog

Drug Addiction - Pipeline Review, H1 2017 Market Overview and trends research report

Radiant insights, inc latest Pharmaceutical and Healthcare disease pipeline guide Drug Addiction - Pipeline Review, H1 2017, provides an overview of the Drug Addiction (Central Nervous System) pipeline landscape. Drug addiction, also called substance dependence or chemical dependency, is a disease that is characterized by a destructive pattern of drug abuse that leads to significant problems involving tolerance to or withdrawal from the substance. Drug addiction symptoms or behaviors include recurrent drug use that results in a lack of meeting important obligations at work, school, or home, inability to sleep, awake at unusual times, unusual laziness, loss of or increased in appetite, changes in eating habits, cold, sweaty palms; shaking hands., red, watery eyes; pupils larger or smaller than usual and unusual smells on breath, body or clothes. Report Highlights Radiant insights, inc Pharmaceutical and Healthcare latest pipeline guide Drug Addiction - Pipeline Review, H1 2017, p...
Read more

All Countries Dialyzer Industry 2013-2028 - Market Size, Share, Outlook, Growth, Key Players and Forecast

The global Dialyzer market was valued at $XX million in 2018, and Radiant Insights, Inc analysts predict the global market size will reach $XX million by the end of 2028, growing at a CAGR of XX% between 2018 and 2028. This report provides detailed historical analysis of global market for Dialyzer from 2013-2018, and provides extensive market forecasts from 2019-2028 by region/country and subsectors. It covers the sales volume, price, revenue, gross margin, historical growth and future perspectives in the Dialyzer market. Download Free Sample Report @ https://www.radiantinsights.com/research/2013-2028-report-on-global-dialyzer-market/request-sample Leading players of Dialyzer including: • Fresenius Medical Care • Baxter • Nipro • Asahi Kasei • Toray • B.Braun • Nikkiso • Medtronic • Kawasumi • Medica • Wego • Lengthen • Peony Medical • Chengdu OCI • Bain Medical Equipment Market split by Type, can be divided into: • Flat Type Dialyzer • Coil Tube Dialyzer • Ho...
Read more

Insights into the Medical Waste Disposal Category: A Comprehensive Procurement Intelligence Report

  Medical Waste Disposal Category Overview The medical waste disposal category is anticipated to grow at a CAGR of 6.0% from 2023 to 2030. Appropriate disposal of medical trash is the key challenge for healthcare providers across the globe. Rising awareness about the benefits of proper medical waste management for treatment, recycling, and disposal of medical trash has boosted the growth of the category. According to the World Health Organization Study Report 2022, countries with low income generate over 0.2 kg of medical trash per day per hospital bed, whereas countries with high income generate hazardous waste of up to 0.5 kg per hospital bed each day. Moreover, rising government initiatives and strict rules and regulations for waste management are also expected to drive the category. For instance, in December 2022, an MOU was signed between the Center for Health Environment Research and Development and Can Tho Central General Hospital under USAID’s Reducing Pollution Project. T...
Read more